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  Antidepressant Efficacy for Depression in Children and Adolescents: Industry- and NIMH-Funded Studies
  [2017.06.01.] - MPT Web-szerkesztőség - Hírkategória: Tudomány

  Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, or equivalent to placebo. In this review, the author discusses several scientific and clinical complexities that are important to understand in reviewing the antidepressant literature: the strengths and weaknesses of meta-analyses; the scientific and regulatory context for the large number of antidepressant trials in the late 1990s and early 2000s; and the distinction between a negative trial, where the treatment does not demonstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any conclusion about efficacy. It is the premise of this review that meta-analyses that include the large number of industrysponsored antidepressant trials distort the picture of antidepressant efficacy for teen depression.

   

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  Antidepressant Efficacy for Depression in Children and Adolescents: Industry- and NIMH-Funded Studies		pdf		2017.06.01.		0,535 Mb

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