On the skin, even under physiological conditions, age shows characteristic morphological and physiological signs. The development of these signs partially depends on internal factors, mainly genes (chronologic or intrinsic aging). Our body and especially the skin is also under the influence of environmental factors that enhance aging (extrinsic aging).
The exact pathomechanism of aging is yet to be uncovered but factors such as genetic, epigenetic modifications, gene expressional changes and other mechanisms (for example: autophagy, inflammation, oxidative stress, shortening of the telomere, DNA damage, senescence of stem cells (glycation) can contribute to molecular changes and to the development of clinical signs. In the present publication, in addition to a more detailed description of previously described underlying mechanisms, we also summarize
the methods suitable for the objective examination of skin aging and briefly discuss possibilities for rejuvenation.

The medical, cosmetological and dermatological use of botulinum toxin is becoming widespread and the growing demand resulted in new indications. Botulinum toxin type A and B are used in medicine, the former is used for cosmetic applications. There are numerous commercially available formulations of botulinum toxin which are not equivalent in efficacy, dosage and antigenicity even for botulinum toxin of the same serotype. In neurological clinical practice botulinum toxin is used to treat dystonias and disorders characterized by spasticity. Registered applications include severe primary axillary hyperhidrosis unresponsive to conventional topical therapy. In Hungary, concerning cosmetological indications, onabotulinum toxin has been approved for the treatment of glabellar-, forehead rhytides and lateral canthal lines (crow’s feet), as well as for primary axillary hyperhidrosis, while abobotulinum toxin has been approved for the treatment of glabellar rhytides, lateral canthal lines (crow’s feet) and axillary hyperhidrosis. In general, the use of botulinum toxin in dermatological and aesthetic indications is safe, most of the side effects can be avoided by using correct injection technique and careful dose selection. Like in every aesthetic treatment precise knowledge of the applied product, functional anatomy and the proper injection technique is essential. The long-term patients’ satisfaction is proven by numerous clinical trials.

Striae distensae are common skin problem, the incidence is higher in females than in males. It is the result of the increased tension on the skin. Although typically asymptomatic, striae distensae may be disfiguring and psychologically distressing to patients. Treatment of striae distensae can be challenging for aestheticans, as no therapy induces complete resolution. Many therapeutic facilities exist to improve the appearance of affected skin. Generally women visit more likely the aestheticians to find a solution for their problems. In our case report we would like to present two cases succesfully treated by mesotherapy.

The number of facial thread–lifting aesthetic procedures has increased in the past 10 years in Hungary.
These non-invading treatments are highly effective for lifting, contouring, volumization, and skin rejuvenation in monotherapy and also in combination with other aesthetic procedures due to stimulation of new collagen synthesis. Unfortunately there are no sufficient clinical studies or scientific basis for the theoretical background and practical possibility. The author would like to offer a short overview of the classification and types of the threads, the indications, efficacy, safety, and techniques of the facial thread-lifting and of the potential combinations. These concepts are based on personal experiences.

The initial stage of venous insufficiency mainly causes aesthetic problems, only a few patients had attended specialists previously with. The aesthetic appearance has become an important aspect nowadays which includes the hands as well as the legs. There is an increasing demand for the treatment of varicosity. It is important, that the intervention will not only be adequate for the function but for the aesthetic aspect. In the last few years a new segment of the professional field called aesthetic phlebology has been expanding, which aims to handle the different aesthetical interventions. This publication outlines the recent possibilities of treating varicosity as well as describing the methods of sclerotherapy in details. For treating small varicose veins, sclerotherapy is a particularly appropriate method which is an injection technique and has been primarily recommended together with the transcutan lasers which have been getting more popular.