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Publikációs adatbázise-GFR kalkulátorKidney and Blood Pressure ResearchHypertonia és Nephrologia
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ISN-KDIGO webinar on HCV Update

Friday, December 15th 9AM EST: HCV Update

Online registration >>

ISN-KDIGO Webinar with Paul Martin (speaker) & Bertram Kasiske (moderator)

It rapidly became apparent after diagnostic testing for HCV was introduced that patients on maintenance hemodialysis (MHD) had a high prevalence of HCV infection and furthermore that HCV acquisition was occurring in the outpatient dialysis setting. Despite screening of blood products, HCV infection has remained highly prevalent in the MHD population. In a multinational study in the period 1996-2002, the prevalence of HCV in US HD patients was 7.4%. A recent update from the period 2012-2015 indicates that the prevalence of HCV in US MHD patients is 6.9%. This suggests that with a US dialysis population of approximately 450,000 patients that there may be 30,000 HCV infected patients on maintenance hemodialysis.

Despite effective strategies to limit spread of HCV among MHD patients, HCV acquisition confirmed by phylogenetic analysis still occurs and typically reflects lack of attention to basic infection prevention measures such as not sharing medication vials between patients and hand hygiene. CDC have been informed about 36 cases of acute HCV in MHD patients in 2014-2015 and have issued an alert stressing the need to adhere to precautions to prevent HCV spread in HD units.

In the general population efforts to identify HCV infected patients have typically focused on individuals with acknowledged risk factors for HCV infection including blood transfusion prior to 1991 and intravenous drug use (IVDU). Included in this high risk group were also dialysis patients reflecting the high prevalence of HCV in this population. However more recently recommendations for testing has included the so-called baby boomer population born between 1945 and 1965 as this “birth cohort” again due to a high prevalence of HCV infection as a consequence of prior IVDU.

In the CKD population HCV testing is recommended as part of the evaluation of CKD, at entry to renal replacement therapy and every 6 months in patients on maintenance hemodialysis ( KDIGO in press).

For an HCV infected CKD patient there are a number of important consequences of infection including an increased risk of death. Cirrhosis and hepatocellular cancer have been implicated in this excess mortality. Another important consequence of HCV infection for a patient with CKD is the effect on potential candidacy for kidney transplantation. HCV infection has been shown to diminish graft and recipient survival following kidney transplant. HCV infected kidney transplant candidates with cirrhosis or focal hepatocellular cancer may not be eligible for isolated kidney transplant and may require consideration for combined liver/kidney transplant, a far more extensive procedure. There is also increasing evidence that HCV infection is not only implicated in causing renal disease often mediated by cryoglobulinemia but also may accelerate the course of CKD in general.

New Cochrane Library Review

ISN Education presents new Cochrane Library materials on Erythropoiesis-stimulating agents for anemia.

Anemia affects nearly all adults with advanced kidney disease and is linked to fatigue, breathlessness, impaired quality of life and physical function, and shorter survival. ESA treatment aims to improve anemia-related symptoms and minimize treatment-related cardiovascular events. Several ESA classes are available for anemia treatment (epoetin alfa, epoetin beta, darbepoetin alfa, methoxy polyethylene glycol-epoetin beta as well as biosimilar ESAs) but whether these drugs have differing benefits and harms is uncertain. This Cochrane review directly compares available ESAs for treatment of anemia among adults with chronic kidney disease.


Suetonia Palmer: Suetonia is a nephrologist based at the University of Otago, Christchurch in New Zealand, and who trained in New Zealand and the USA. She is an Editor for Cochrane Kidney and Transplant.

Giovanni Strippoli: Giovanni is a nephrologist based at the University of Bari in Italy, who also trained at the Sydney School of Public Health, Australia. He is an Editor for Cochrane Kidney and Transplant and the journal Nephrology, Dialysis and Transplantation.

Discover more Cochrane Library materials on ISN Education >>

New research article published from the Global Outreach Postings (GOP) Program

ISN Education presents a new research article published from the Global Outreach Postings (GOP) Program >>

Submitted by Dr. Olga Chub, "Extended Spectrum Beta-Lactamase Production in uropathogens from hospitalized patients with chronic pyelonephritis">> has been published on ISN Education and will be published in the next edition of The Open Urology & Nephrology Journal>> under a specific ISN-GOP heading.

Volume 8, 2015
Read our previous GOP article by Mayoor Prabhu in the latest Volume of the Open Urology & Nephrology Journal.
Manual Acute PD with Rigid Catheters: A Relook >>

ISN Education’s GOP program aims to give nephrologists from emerging countries a chance to have their research reviewed and published. Submit your manuscript today >>

Click here to view all GOP articles >>

ISN Education's top content from the first half of 2015

Az alábbi összefoglalóban visszatekintünk az International Society of Nephrology (ISN) távképzési programjának első félévére, a legnépszerűbb oktatási anyagokra.

Az összefoglaló letölthető ide kattintva >>

ISN Education: interventions to delay CKD progression

This week ISN Education focuses on key interventions to delay CKD progression.
ISN Education brings a selection of presentations on "How to effectively retard progression in CKD" from ISN's World Congress of Nephrology, 2015.
Also, the recorded version of the live webinar, "Update on slowing CKD progression," the second part of a two-part series by George Bakris, is now available for on-demand viewing.

World Congress of Nephrology 2015
ISN Education releases presentations from WCN 2015 session "Lost in translation: How to effectively retard progression in CKD"

Session Presentations:

What have we learned on prevention of progression? >>
By Maarten Taal

The link between AKI and CKD >>
By Paul Lawrence Kimmel

Cost-Effectiveness of Renal Outcome Modification by Educational Intervention for Moderate-stage CKD in Japan >>
By Masahide Kondo

Non diabetic vs Diabetic >>
By Piero Ruggenenti

Click here to view more WCN 2015 presentations >>

ISN Education 'Ask the Experts'
Az ISN "Ask the Expert" szekciójában feltett legújabb kérdések és a rájuk adott válaszok ide kattintva tekinthetőek meg >>

Kérdést ide kattintva tehet fel >>

Presentations from ISN's World Congress of Nephrology
ISN Education releases the Plenary Session presentations from ISN's World Congress of Nephrology 2015. These were presented by speakers with varying backgrounds in nephrology whose biographies you can read here http://www.wcn2015.org/program/speakers

Hypertension and kidney disease: The fault is not in our stars, but may be in our embryos:
http://www.theisn.org/education/education-topics/hypertension/item/1996-hypertension-and-kidney-disease-the-fault-is-not-in-our-stars-but-may-be-in-our-embryos >>)
By Barry Brenner

Planetary health: why health matters for human civilization?
(http://www.theisn.org/education/education-topics/general-nephrology/item/1995-planetary-health-why-health-matters-for-human-civilization >>)
By Richard Horton

Why and how ageing makes us sick?
(http://www.theisn.org/education/education-topics/general-nephrology/item/1998-why-and-how-ageing-makes-us-sick >>)
By Tom Kirkwood

Intestinal Microbiota in Health and Disease
(http://www.theisn.org/education/education-topics/general-nephrology/item/1997-intestinal-microbiota-in-health-and-disease >>)
By Dusko Ehrlich

Click here to view all WCN 2015 plenary presentations:
(http://www.theisn.org/education/education-topics/general-nephrology/item/1997-intestinal-microbiota-in-health-and-disease >>)

ISN Education: 18th & 30th Vicenza Courses on PD
ISN Education közzétette weboldalán a "18th & 30th Vicenza Courses on PD" előadásait.
Az előadások megtekinthetőek ide kattintva >>

A 2015.02.17-20-i San Diego-i AKI & CRRT Konferencia előadásai
Kedves Kollégák!
Az ISN közzétette weboldalán a 2015. február 17-20. között San Diegoban rendezett AKI & CRRT Konferencia "Updates in ICU Medicine: Controversies, Challenges and Solutions"" fő témában elhangzott előadásait.
A következő linkre kattintva Dr. Mark Okusa előadását hallgathatják meg:

Neuro Immune Control of AKI and Inflammation >>
A CRRT szekció összes előadása ide kattintva tekinthető meg >>

A World Congress of Nephrology 2015 előadásai elérhetőek az ISN honlapján
Az ISN honlapján elérhetővé tette a Wold Congress of Nephrology (Cape Town, South Africa, 2015. március 13-17.) alábbi szekcióinak előadásait:
- Preventable AKI
- Towards new therapeutic strategies of anemia for renal patients
- Water Intake - the good, the bad and the ugly
- Hypertension and the metabolic syndrome: New anthropologic and pathophysiologic insights
- Membranous nephropathy: Toward personalized diagnosis and therapy
- Lupus nephritis: A story of old and new drugs
Az előadások megtekinthetőek ide kattintva >>

WCN 2015 Renal Biopsy Histology Procedure Manual
This manual provides an overview of the use of various techniques to assess a renal biopsy. Technical procedures for allocation and processing and staining the renal biopsy for light microscopy, immunofluorescence and electron microscopy, and procedures for commonly used special stains are provided.
Click here to read the manual >>
About the Authors
Agnes B. Fogo and J. Charles Jennette are experienced renal pathologists, based at Vanderbilt University in Nashville, TN and University of North Carolina, Chapel Hill, NC, respectively.

ISN távoktatás: Dialysis Vascular Access
ISN Education is pleased to offer a new interactive module on dialysis vascular access. This module provides an overview of the anatomy, surgical techniques, access monitoring, cannulation methods and introduction to endovascular interventional treatment to maintain the patency of this 'lifeline'.
A self assessment component at the end of each topic will keep the learner engaged all through the module.
Click here to learn more about and access the VA Learning Module >>
Az ISN Education bemutatja a 2014 márciusában San Diegoban rendezett CRRT Konferencia előadásait >>

Vesebiopsziával kapcsolatos továbbképzések elérhetősége:
Az ISN vesebiopsziával kapcsolatos szakmai anyagai megtekinthetőek ide kattintva >>
Kiváló továbbképzési lehetőséget biztosítanak tagjaink számára!

A pathológiai témájú továbbképzések elérhetősége:
Az ISN pathológiai témájú továbbképzései >>